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Disease and Illnesses

Illustration of a T lymphocyte white blood cell, depicted in blue, attacking a cancer cell, shown in red

Scientists Engineered Cancer-Fighting Cells Inside Patients’ Bodies—and Two Early Trials Show Promise

Two recent studies show the novel therapy works in people with multiple myeloma, but researchers are trying to minimize side effects

The Black Death may have killed more than half of Europe's population within just a few years.

A Volcanic Eruption in 1345 May Have Triggered a Chain of Events That Brought the Black Death to Europe

Ash from the explosion may have led to crop failure and famine in southern Europe, leading some Italian cities to import grain—which possibly carried fleas infected with the bubonic plague

A microscope image of HIV particles, in red, replicating from an infected cell, in blue.

A New Trial Put Immune System-Boosting Therapies to the Test to Fight HIV, Raising Hopes for Keeping the Virus at Bay

In the small study, seven out of ten participants maintained low levels of HIV for several months after receiving the experimental treatment and stopping their usual daily medications

The World Health Organization conditionally recommends the use of GLP-1 drugs, including tirzepatide, marketed as Mounjaro and Zepbound, for obesity treatment. 

Here’s What the World Health Organization Had to Say About GLP-1s in its First-Ever Guideline on the Drugs

The health agency supports the long-term use of the medications in combination with a healthy diet and exercise, and calls for equitable access to the drugs

Smithsonian magazine's picks for the best books about science in 2025 include Replaceable You, Dinner With King Tut and North to the Future.

The Best Books of 2025

The Ten Best Science Books of 2025

From “experimental archaeology” to the mysterious appeal of exploration, the wide-ranging subjects detailed in these titles captivated Smithsonian magazine’s science contributors this year

A digital illustration of an HIV-infected T cell. Once infected, the immune cell is hijacked by the virus to produce and release many new viral particles before dying. As more T cells are destroyed, the immune system is progressively weakened.

New Trials Hint That ‘Functional Cure’ for HIV May Be Within Reach, Helping Some Patients Achieve Lasting Remission

People infected with HIV must take antiretroviral drugs for life. But engineered antibodies appeared to suppress the virus for certain participants in recent trials in Africa and Europe

Oliver and his father, Ricky

This Toddler Was the First Person to Receive a Test Treatment for a Rare Genetic Disorder. Nine Months Later, His Progress Is Inspiring Hope

Oliver Chu is one of five kids participating in a clinical trial investigating a gene therapy for Hunter syndrome, a disorder with symptoms akin to childhood dementia that limits life expectancy

Researchers have developed a promising new antivenom effective against more than a dozen venemous snake species, according to trials in mice.

Researchers Create a New Antivenom That Can Combat Bites From 17 Snake Species, Trials in Mice Suggest

Snakebites are among the deadliest neglected tropical diseases, and scientists have long been searching for more effective ways to prevent their devastating effects

Thousands of men died as Napoleon's army retreated from Russia in 1812.

Cold, Hungry and Thirsty, Napoleon’s Troops Also Suffered From Several Diseases as They Retreated From Russia

New research finds evidence of two previously undocumented infections that likely plagued the French emperor’s Grande Armée during the retreat from Moscow

Nobel Committee Secretary-General Thomas Perlmann addresses journalists during an October 6 press conference announcing the 2025 Nobel Prize in Physiology or Medicine in Stockholm, Sweden.

Trio of Researchers Awarded Nobel Prize for Groundbreaking Discovery of Immune Cells That Prevent Autoimmune Disease

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi’s research revealed a new class of cells shaking up scientists’ understanding of the human immune system

Huntington's disease gradually damages the caudate nucleus, pictured in red. 

Experimental Gene Therapy Successfully Treats Huntington’s Disease for the First Time

Preliminary results from a small study offer hope for treatment of the degenerative disease

“Brain rot” was the Oxford Word of the Year 2024.

Can You Really ‘Rot’ Your Brain by Scrolling Too Much on Your Smartphone?

While that message has been spread on social media, researchers are just beginning to understand how the devices affect the mind

The vaccine can be administered to koalas in a single dose.

A New Vaccine Could Help Save Australia’s Beloved Koalas From Chlamydia, and It Just Got Approved

The disease causes blindness, infertility, severe urinary tract infections and death in the iconic, furry marsupials, which are also threatened by habitat loss

An aardvark emerges from its burrow.

Could Aardvark Burrows Be Ground Zero for the Next Pandemic?

Animals of all kinds mix and mingle in the underground refuges, offering troubling opportunities for diseases to jump species

Demonstrators in Berlin last year advocated for increased awareness of ME/CFS.

Scientists Find Links to Chronic Fatigue Syndrome in Genes and in the Gut Microbiome

Two studies present new data on ME/CFS, offering “credibility and validity” to the experiences of patients struggling with symptoms

Scientists are currently studying whether cannabis use may cause schizophrenia.

Inside the Quest to Understand the Link Between Cannabis and Schizophrenia

Recent studies have examined the relationship between the drug and psychoses and looked at how the brain responds to the substance

Seeing a potentially infectious person might kickstart the body's immune system, according to a new study.

The Mere Sight of Someone Sick Triggers an Immune Response, Study Suggests

Researchers equipped study participants with virtual reality headsets and observed how their brains and immune systems reacted to avatars with signs of illness

New light microscopy techniques can distinguish objects down to less than ten nanometers. 

These Super-Resolution Microscopes Are Revealing the Inner Lives of Cells

Advanced light microscopy techniques are giving scientists a new understanding of human biology and what goes wrong in diseases

Early detection cancer tests are showing signs of promise, but some researchers still have reservations.

Cancer DNA Can Be Detected in the Bloodstream Up to Three Years Before Diagnosis, Study Suggests

For a few individuals, scientists found genetic material from cancerous tumors in blood samples taken years before they were diagnosed through traditional methods

A Late Neolithic skull. For the recent study, scientists extracted DNA from skulls and teeth to look for traces of diseases.

With Ancient DNA, Scientists Have Mapped 37,000 Years of Disease Across Europe and Asia

Zoonoses—diseases that spread from animals to humans—began to gain prevalence some 6,500 years ago with the rise of animal husbandry, a new study suggests

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