The Vast Influence of the Wee Microbe

The Vast Influence of the Wee Microbe

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Even more fascinating than the resurgence of various diseases are some of the new techniques researchers are working on to fight them, according to the folks at Pfizer, Inc, the firm that sponsored the exhibition.

The first synthetic drugs were produced by copying the chemical recipes of natural antibiotics. Today, researchers must work constantly to create new forms of antibiotics because microbes have the ability to evolve and become resistant to both the natural drugs and their synthetic cousins.

One technique that chemists are developing to outsmart the microbe involves treatment strategies based on genetic makeup. By studying the complete genetic blueprints of microbes, chemists can analyze the molecular processes the microbe needs to survive. Then they can produce an entirely new class of drugs—drugs targeting important processes the microbe has never had to defend before. Not surprisingly, these are being referred to as designer drugs.

Work is also being done on the link between bacteria and chronic diseases. I always thought that gastric ulcers, for example, were caused by bad diet and stress. But no, it seems that in most cases there is a bacterium that gets into the stomach lining and infects it, causing a lesion. Even atherosclerosis might be caused by yet another of these disagreeable little creatures. The latest thinking also implicates microbes in arthritis and cancer.

AIDS research has helped, as it explores the mysteries of the human immune system, for natural immunity has always been the best defense against microbes. It's rather like the way wars have given us new surgical techniques, if nothing else. To get back to the show: it covers a lot of ground. There is an Egyptian tomb containing a photograph of the face of Ramses V's mummy — unwrapped. One can plainly see pockmarks that indicate the virus that attacked Ramses; it apparently killed him around 1151 B.C. There is a copy of an Egyptian tablet showing the first pictorial record of polio. These diseases are not new to the human race.

In a different area we visit a catacomb below Paris, where a robotic figure wearing a beaked mask describes the Black Plague, which killed an estimated 56 million people, a third of Europe's population, in the 14th century. The mask, or something like it, was believed to protect against bubonic plague, which people thought came from poisonous gas in the earth. Actually, it was microbes. They lived in the fleas that rode around on rats, and thus spread to virtually every household on the Continent.

An Aztec ruin in the show displays replicas of those little clay figures the Aztecs loved to make, illustrating various diseases and malformations. Even Main Street comes in for treatment with a short video describing the discovery of penicillin in 1928. (Pfizer, to give it credit, pioneered in the mass production of penicillin in World War II. The firm's labs also developed terramycin, in 1950, and tetracycline, in 1962.) Also, we are treated to a series of holograms that present several noted microbes — Ebola and E. coli, for instance — as three-dimensional sculptures. Are they beautiful? Well ...

Maybe, but I am reminded that infectious diseases are still the leading cause of death in this world. Even as we fight off renewed attacks by diseases we thought we had licked, new ones develop. Lyme disease. AIDS. Ebola. Legionnaires' disease. Hantavirus pulmonary syndrome, which I had never heard of but already is rampaging through 20 states.

It was Antonie van Leeuwenhoek who first noted these wee "animalcules" in the microscope that he invented in 1683. It took another two centuries before people connected them to disease.

Let us hope that the scientists of the future who see this memorable show don't wait that long to tell us about their discoveries.


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